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+Slowing Aging
+=============
+
+- Avoid DNA damage (wear sunscreen)
+- Eat less - caloric restriction
+- Eat less protein
+- Do exercise (HIIT)
+- Be cold
+- Be hot
+
+... these trigger longevity genes to trick body into preserving genome
+
+
+Reversing aging
+===============
+
+Theory
+------
+
+- Shinya Yamanaka discovered 4 factors that reset epigenome of cell back to pluriportent stem cell
+  - Myc, Oct3/4, Sox2 and Klf4
+  - dont do it all, would turn into tumor
+  - suggests there are ways to revert cells and reverse ageing
+- David Sinclar's lab reversed aging in old mice so they could see like they were young again
+  - used 3/4 of the reprogramming factors, not Myc as causes cancer
+  - can turn system on and off to limit reversal
+
+
+Resources
+=========
+
+- Veratasium How to Slow Aging:
+https://www.youtube.com/watch?v=QRt7LjqJ45k
+
+- JRE David Sinclair #1:
+https://www.youtube.com/watch?v=HOTS0HS7aq4
+
+Notes:
+Calorie restriction, mostly vegetarian diet, avoid sugar and carbs. 
+On weekends, he exercises at the gym and then sits in a hot sauna before plunging himself into an ice-cold pool, as well as tracks his biomarkers regularly.
+Takes vitamin D, vitamin K2, and aspirin. 
+Takes each morning: resveratrol, NMN, and metformin
+
+- JRE David Sinclair #2:
+https://www.youtube.com/watch?v=ZGLL77wYxe8
+
+0:00 The new book, resveratrol
+7:00 NMN and NAD+, metformin and exercise
+18:00 Sinclair’s family went on a safari
+48:30 back to the anti-aging book, longevity
+52:20 Sinclair’s healthy 80 year old father: “He’s fitter than me”, his rebel grandmother
+1:10:00 intermittent fasting
+1:15:50 I.V. NAD+
+1:18:00 nutrition, yogurt and other food
+1:32:00 resveratrol, colorful foods
+1:41:00 sleep
+1:45:40 what should people be doing? (Sinclair is wrong about airport scanners)
+1:48:25 NMN and NR online
+1:50:25 CRISPR/ genetic engineering
+2:08:00 blood rejuvenation
+2:12:50 what is on the horizon? senescence cells, “We’ve learned how to fly…”
+
+- Age reduction breakthrough:
+https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduction-breakthrough/
+
+- Yamanaka paper:
+https://www.cell.com/fulltext/S0092-8674(06)00976-7