You can not select more than 25 topics
Topics must start with a letter or number, can include dashes ('-') and can be up to 35 characters long.
67 lines
2.1 KiB
67 lines
2.1 KiB
Slowing Aging |
|
============= |
|
|
|
- Avoid DNA damage (wear sunscreen) |
|
- Eat less - caloric restriction |
|
- Eat less protein |
|
- Do exercise (HIIT) |
|
- Be cold |
|
- Be hot |
|
|
|
... these trigger longevity genes to trick body into preserving genome |
|
|
|
|
|
Reversing aging |
|
=============== |
|
|
|
Theory |
|
------ |
|
|
|
- Shinya Yamanaka discovered 4 factors that reset epigenome of cell back to pluriportent stem cell |
|
- Myc, Oct3/4, Sox2 and Klf4 |
|
- dont do it all, would turn into tumor |
|
- suggests there are ways to revert cells and reverse ageing |
|
- David Sinclar's lab reversed aging in old mice so they could see like they were young again |
|
- used 3/4 of the reprogramming factors, not Myc as causes cancer |
|
- can turn system on and off to limit reversal |
|
|
|
|
|
Resources |
|
========= |
|
|
|
- Veratasium How to Slow Aging: |
|
https://www.youtube.com/watch?v=QRt7LjqJ45k |
|
|
|
- JRE David Sinclair #1: |
|
https://www.youtube.com/watch?v=HOTS0HS7aq4 |
|
|
|
Notes: |
|
Calorie restriction, mostly vegetarian diet, avoid sugar and carbs. |
|
On weekends, he exercises at the gym and then sits in a hot sauna before plunging himself into an ice-cold pool, as well as tracks his biomarkers regularly. |
|
Takes vitamin D, vitamin K2, and aspirin. |
|
Takes each morning: resveratrol, NMN, and metformin |
|
|
|
- JRE David Sinclair #2: |
|
https://www.youtube.com/watch?v=ZGLL77wYxe8 |
|
|
|
0:00 The new book, resveratrol |
|
7:00 NMN and NAD+, metformin and exercise |
|
18:00 Sinclair’s family went on a safari |
|
48:30 back to the anti-aging book, longevity |
|
52:20 Sinclair’s healthy 80 year old father: “He’s fitter than me”, his rebel grandmother |
|
1:10:00 intermittent fasting |
|
1:15:50 I.V. NAD+ |
|
1:18:00 nutrition, yogurt and other food |
|
1:32:00 resveratrol, colorful foods |
|
1:41:00 sleep |
|
1:45:40 what should people be doing? (Sinclair is wrong about airport scanners) |
|
1:48:25 NMN and NR online |
|
1:50:25 CRISPR/ genetic engineering |
|
2:08:00 blood rejuvenation |
|
2:12:50 what is on the horizon? senescence cells, “We’ve learned how to fly…” |
|
|
|
- Age reduction breakthrough: |
|
https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduction-breakthrough/ |
|
|
|
- Yamanaka paper: |
|
https://www.cell.com/fulltext/S0092-8674(06)00976-7
|
|
|