Slowing Aging
=============

- Avoid DNA damage (wear sunscreen)
- Eat less - caloric restriction
- Eat less protein
- Do exercise (HIIT)
- Be cold
- Be hot

... these trigger longevity genes to trick body into preserving genome


Reversing aging
===============

Theory
------

- Shinya Yamanaka discovered 4 factors that reset epigenome of cell back to pluriportent stem cell
  - Myc, Oct3/4, Sox2 and Klf4
  - dont do it all, would turn into tumor
  - suggests there are ways to revert cells and reverse ageing
- David Sinclar's lab reversed aging in old mice so they could see like they were young again
  - used 3/4 of the reprogramming factors, not Myc as causes cancer
  - can turn system on and off to limit reversal


Resources
=========

- Veratasium How to Slow Aging:
https://www.youtube.com/watch?v=QRt7LjqJ45k

- JRE David Sinclair #1:
https://www.youtube.com/watch?v=HOTS0HS7aq4

Notes:
Calorie restriction, mostly vegetarian diet, avoid sugar and carbs. 
On weekends, he exercises at the gym and then sits in a hot sauna before plunging himself into an ice-cold pool, as well as tracks his biomarkers regularly.
Takes vitamin D, vitamin K2, and aspirin. 
Takes each morning: resveratrol, NMN, and metformin

- JRE David Sinclair #2:
https://www.youtube.com/watch?v=ZGLL77wYxe8

0:00 The new book, resveratrol
7:00 NMN and NAD+, metformin and exercise
18:00 Sinclair’s family went on a safari
48:30 back to the anti-aging book, longevity
52:20 Sinclair’s healthy 80 year old father: “He’s fitter than me”, his rebel grandmother
1:10:00 intermittent fasting
1:15:50 I.V. NAD+
1:18:00 nutrition, yogurt and other food
1:32:00 resveratrol, colorful foods
1:41:00 sleep
1:45:40 what should people be doing? (Sinclair is wrong about airport scanners)
1:48:25 NMN and NR online
1:50:25 CRISPR/ genetic engineering
2:08:00 blood rejuvenation
2:12:50 what is on the horizon? senescence cells, “We’ve learned how to fly…”

- Age reduction breakthrough:
https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduction-breakthrough/

- Yamanaka paper:
https://www.cell.com/fulltext/S0092-8674(06)00976-7