personal-site/content/text/anti-aging.txt

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2021-10-14 07:42:11 +00:00
Slowing Aging
=============
- Avoid DNA damage (wear sunscreen)
- Eat less - caloric restriction
- Eat less protein
- Do exercise (HIIT)
- Be cold
- Be hot
... these trigger longevity genes to trick body into preserving genome
Reversing aging
===============
Theory
------
- Shinya Yamanaka discovered 4 factors that reset epigenome of cell back to pluriportent stem cell
- Myc, Oct3/4, Sox2 and Klf4
- dont do it all, would turn into tumor
- suggests there are ways to revert cells and reverse ageing
- David Sinclar's lab reversed aging in old mice so they could see like they were young again
- used 3/4 of the reprogramming factors, not Myc as causes cancer
- can turn system on and off to limit reversal
Resources
=========
- Veratasium How to Slow Aging:
https://www.youtube.com/watch?v=QRt7LjqJ45k
- JRE David Sinclair #1:
https://www.youtube.com/watch?v=HOTS0HS7aq4
Notes:
Calorie restriction, mostly vegetarian diet, avoid sugar and carbs.
On weekends, he exercises at the gym and then sits in a hot sauna before plunging himself into an ice-cold pool, as well as tracks his biomarkers regularly.
Takes vitamin D, vitamin K2, and aspirin.
Takes each morning: resveratrol, NMN, and metformin
- JRE David Sinclair #2:
https://www.youtube.com/watch?v=ZGLL77wYxe8
0:00 The new book, resveratrol
7:00 NMN and NAD+, metformin and exercise
18:00 Sinclairs family went on a safari
48:30 back to the anti-aging book, longevity
52:20 Sinclairs healthy 80 year old father: “Hes fitter than me”, his rebel grandmother
1:10:00 intermittent fasting
1:15:50 I.V. NAD+
1:18:00 nutrition, yogurt and other food
1:32:00 resveratrol, colorful foods
1:41:00 sleep
1:45:40 what should people be doing? (Sinclair is wrong about airport scanners)
1:48:25 NMN and NR online
1:50:25 CRISPR/ genetic engineering
2:08:00 blood rejuvenation
2:12:50 what is on the horizon? senescence cells, “Weve learned how to fly…”
- Age reduction breakthrough:
https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduction-breakthrough/
- Yamanaka paper:
https://www.cell.com/fulltext/S0092-8674(06)00976-7