68 lines
2.1 KiB
Plaintext
68 lines
2.1 KiB
Plaintext
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Slowing Aging
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- Avoid DNA damage (wear sunscreen)
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- Eat less - caloric restriction
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- Eat less protein
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- Do exercise (HIIT)
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- Be cold
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- Be hot
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... these trigger longevity genes to trick body into preserving genome
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Reversing aging
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===============
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Theory
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------
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- Shinya Yamanaka discovered 4 factors that reset epigenome of cell back to pluriportent stem cell
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- Myc, Oct3/4, Sox2 and Klf4
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- dont do it all, would turn into tumor
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- suggests there are ways to revert cells and reverse ageing
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- David Sinclar's lab reversed aging in old mice so they could see like they were young again
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- used 3/4 of the reprogramming factors, not Myc as causes cancer
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- can turn system on and off to limit reversal
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Resources
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=========
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- Veratasium How to Slow Aging:
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https://www.youtube.com/watch?v=QRt7LjqJ45k
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- JRE David Sinclair #1:
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https://www.youtube.com/watch?v=HOTS0HS7aq4
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Notes:
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Calorie restriction, mostly vegetarian diet, avoid sugar and carbs.
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On weekends, he exercises at the gym and then sits in a hot sauna before plunging himself into an ice-cold pool, as well as tracks his biomarkers regularly.
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Takes vitamin D, vitamin K2, and aspirin.
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Takes each morning: resveratrol, NMN, and metformin
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- JRE David Sinclair #2:
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https://www.youtube.com/watch?v=ZGLL77wYxe8
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0:00 The new book, resveratrol
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7:00 NMN and NAD+, metformin and exercise
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18:00 Sinclair’s family went on a safari
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48:30 back to the anti-aging book, longevity
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52:20 Sinclair’s healthy 80 year old father: “He’s fitter than me”, his rebel grandmother
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1:10:00 intermittent fasting
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1:15:50 I.V. NAD+
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1:18:00 nutrition, yogurt and other food
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1:32:00 resveratrol, colorful foods
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1:41:00 sleep
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1:45:40 what should people be doing? (Sinclair is wrong about airport scanners)
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1:48:25 NMN and NR online
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1:50:25 CRISPR/ genetic engineering
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2:08:00 blood rejuvenation
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2:12:50 what is on the horizon? senescence cells, “We’ve learned how to fly…”
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- Age reduction breakthrough:
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https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduction-breakthrough/
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- Yamanaka paper:
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https://www.cell.com/fulltext/S0092-8674(06)00976-7
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